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NCI Offers Checkpoint-Resistant Cancer Cell Line for Licensing
The CRISPR-engineered mouse colon-cancer model removes B2m and MHC-I antigen presentation to support preclinical research on resistance to PD-1 and PD-L1 therapies.
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Health & Science
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NIH Offers Cancer Methylation Classifier for Licensing
The prototype platform uses 16,567 CNS reference profiles across 133 diagnostic classes and includes separate kidney-tumor work; commercialization and regulated deployment remain prospective.
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FDA Updates Fresh-Cut Produce Safety Guide
The final nonbinding guide adds antimicrobial, supply-chain and time-temperature examples while clarifying which ready-to-eat produce it covers.
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El Niño Suppresses Pacific Chlorophyll in NASA’s PACE View
June satellite maps show substantially lower chlorophyll across the central equatorial Pacific as weaker trade winds reduced nutrient-rich upwelling.
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FDA Proposes Class II Path for 3D Breast Scans
The agency would move digital breast tomosynthesis systems from premarket approval to special controls and 510(k) review, while keeping dedicated breast CT in Class III.
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CMS Proposes RAPID Medicare Device Path
The voluntary proposal would coordinate Medicare coverage reviews with FDA authorization for selected breakthrough devices, with final coverage goals of 60 or 90 days.
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WHO Cuts East Africa Kala-Azar Regimen to 14 Days
New guidance recommends the first sodium-stibogluconate-free option for many patients and shorter regimens for a related skin condition.
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Neurons Encoded Grammar and Context Before Speech
Recordings from eight epilepsy patients let NIH-funded researchers map language features at single-cell resolution during conversation.
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FDA Approves First Regulatory T-Cell Therapy for Stem-Cell Transplants
Tregzi improved one-year chronic GVHD-free survival to 78% in a randomized trial of 187 adults, compared with 38.4% after a standard transplant.
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NIH Cancer Library Spans 665 Lab Models Across 25 Tumor Types
The international resource links patient-derived organoids and other models with molecular and clinical data, including rare cancers and donors of non-European ancestry.
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NIH Opens ORIVA to Scale Human-Based Research and Reduce Animal Use
The new office will coordinate tissue models, computational tools and other New Approach Methodologies across NIH and with regulators.
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NIH Consortium Builds First Broad Atlas of Senescent Cells
The SenNet papers introduce 'senotypes' to distinguish rare cells by tissue and condition, a step toward studying harmful and beneficial roles without treating them as one group.
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NIH Study Maps a Midlife Shift in the Brain's Immune Cells
A molecular atlas of 40 healthy human hippocampi found microglia declined as inflammatory and peripheral-like immune cells became more prominent from about ages 50 to 75.
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Prediabetes Lifestyle Program Cut Risk of Multiple Chronic Conditions
A 1,173-person NIH trial found a 21% lower risk of developing two chronic conditions; metformin did not significantly reduce that outcome.
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NIH Expands All of Us Research Dataset to 747,000 Participants
The ninth curated release links more than 535,000 whole genomes with nearly 482,000 electronic health records and adds proteomics, RNA and long-read sequencing.
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Circular-RNA Blood Model Nearly Tripled Alzheimer’s Symptom-Risk Estimate
An NIH-funded study of more than 1,200 people found 34 circular RNAs predicted progression better than a leading protein marker, but no clinical assay is yet available.
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FDA Reopens BHT Food-Additive Comment Period Through Aug. 31
The agency is seeking additional information for its post-market reassessment and says it has not reached a new safety conclusion about the preservative.
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OSHA Safe + Sound Week Runs Aug. 10–16 With Three-Part Safety Framework
The national workplace-safety week centers on management leadership, worker participation and a systematic process for finding and fixing hazards.
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NIH Cancer Model Library Spans 25 Tumor Types and 2,780 Donors
The international HCMI resource links 665 patient-derived laboratory models with molecular and clinical data for precision-oncology research.
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NASA IXPE Magnetar Data May Show Vacuum Birefringence for First Time
A 140-hour campaign recorded unusually strong X-ray polarization around 1E 1547-5408, offering the clearest evidence yet for a 90-year-old physics prediction.
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Queen Sweat Bee Pheromones Help Decide Whether Daughters Stay, Study Finds
A multiyear Panama study linked stronger queen chemical signals to suppressed ovarian development and a greater chance that daughters remained as nest helpers.
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Chris Williams Returns After 241 Days, 3,856 Orbits and Two Spacewalks
NASA’s first-time astronaut traveled more than 102 million miles while supporting cancer research, materials experiments and station repairs.
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County Uninsured Rates Rose in 427 Places and Fell in Just 65, Census Says
New small-area estimates show the median county rate increased to 9.8% in 2024 and fewer counties stayed below the 10% threshold.
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ALS Blood Protein Panel Predicted Symptom Onset Within About 18 Months
A longitudinal study of people at elevated genetic risk found a 19-protein panel could estimate when clinical ALS would emerge, but broader validation remains necessary.
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Brain Immune Cells Shift Sharply From Midlife, Human Study Finds
A 40-person postmortem study found resident microglia declining from roughly ages 50 to 75, alongside stronger inflammatory signatures—but not proof of dementia causation.
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WHO Updates Dementia Guidance: Up to 45% of Risk Is Modifiable
The recommendations emphasize physical and social activity, tobacco and alcohol reduction, cardiometabolic care, hearing support and less air-pollution exposure.
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FDA Picks Dexcom for First TEMPO Digital Health Pilot
The glucose program will generate real-world evidence inside Medicare’s ACCESS model as FDA plans up to about 10 participants in each of four clinical-use areas.
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FDA Approves First Oral PCSK9 Drug After 56%–59% LDL Cuts vs. Placebo
Lipfendra adds a once-daily tablet to a cholesterol-lowering drug class previously available only by injection; the pivotal endpoint was LDL change at 24 weeks.
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FDA Approves First Orexin-Targeting Drug for Narcolepsy Type 1
Orzeyful, or oveporexton, is the first approved medicine designed to restore the missing wakefulness signal behind the disorder’s full symptom pattern.
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FDA Licenses First U.S. Freeze-Dried Plasma Product
Ezplaz can be stored at room temperature and rapidly reconstituted for adult transfusion when other plasma products are unavailable.
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FDA Revokes Orange B Rule, Proposes Ending Citrus Red No. 2
Orange B’s revocation is final, while the Citrus Red No. 2 action remains a proposal open for comment through August 24.
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Museum DNA Completed a Family Tree for Hawaiʻi’s Native Birds
The analysis connects 17 living honeycreeper species with 18 that vanished after 1778 and two known only from fossils. It also reveals a burst of diversification and genetic mixing.
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PUNCH Tracked One Solar Storm to a 30-Minute Arrival Window
The first retrospective test beat the five-hour window NASA associates with current methods. It involved one eruption, and the analysis is still under journal review.
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A 19-Protein Blood Panel Narrowed the Timing of ALS Symptoms
The model estimated symptom onset with a 1.62-year average error in a high-risk research cohort. It is not a clinical test, and its UK Biobank replication relied on approximated dates.
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NASA Sets Three August Spacewalks to Rewire the ISS for More Power—and Its Eventual Exit
The three outings will prepare another power channel for a roll-out solar array, replace a communications antenna and connect systems needed for station operations and its eventual deorbit.
explainer
DEA Could Put Concentrated 7-OH in Schedule I Within Days. Here’s What the Record Shows
The action is not yet in force and does not formally cover ordinary kratom leaf below the proposed threshold. The evidence shows real opioid risks, major data gaps and a narrow public process that closed after July 31.